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ADDEOLIC®: A patented ingredient for perfect intimate well-being

About ADDEOLIC®: an ingredient designed for urinary tract health

ADDEOLIC® is a unique and original patented ingredient designed for urinary tract health. It was developed specifically for use in food supplements for women.

Its originality lies in its composition, which combines 3 ingredients:

  • Cranberry (Vaccinium macrocarpon Aiton) titrated to 20% PACs*
  • Chinese cinnamon essential oil (Cinnamomum cassia Blume)
  • Basil essential oil (Ocimum basilicum)

These three ingredients act in synergy to improve urinary comfort in women.

 

In addition, cranberry is widely recognised for its ability to prevent intimate discomfort. The main reason for this is its high concentration in PACs*. Essential oils have also been proven to have many beneficial health properties. Several studies have in fact demonstrated their health benefits (see below).

 

ADDEOLIC® uses a specific technology involving micro-encapsulation of essential oils combined with cranberry. It comes in the form of a homogeneous powder, ideal for food supplements in capsule, tablet and other dry forms.

A study has also been carried out on ADDEOLIC® alone:

  • A use study conducted in 60 women

 

Dosage of ADDEOLIC®

480 mg of ADDEOLIC® per day (2 capsules) provides:

  • 200 mg of cranberry extract, equivalent to 36 mg of PACs* (according to the BL-DMAC method)
  • 48 mg of Chinese cinnamon essential oil
  • 14 mg of basil essential oil

*Proanthocyanidins

 

Some key figures on urinary discomfort1

  • 56% of French women have suffered from a urinary infection and/or discomfort at least once in their lives
  • An infectious episode lasts on average 5 days
  • In 50% of women, the infection will recur once in the course of the year, in 21% it will recur more than twice
  • 38% of French women having contracted an infection have already consumed cranberries as a means of prevention. They consume it mainly in the form of a juice or food supplement.

  

What is a urinary tract infection?

A urinary tract infection is a bacterial infection of the urinary tract. In concrete terms, the bacteria in the intestinal microbiota migrate and contaminate the urogenital region.

In most cases the infection affects the bladder, which becomes inflamed. It is what we call cystitis. Cystitis causes several symptoms that significantly impair quality of life, especially in case of recurrence. Symptoms are of varying intensity and include:

  • Pain or burning sensations before, during and after urination
  • A more frequent or more intense need to urinate
  • Abdominal pain or spasms
  • Haematuria
  • Fatigue

Urinary tract infections affect mostly women, rarely men. This is because the urethral canal of a woman is shorter, making it easier for intestinal bacteria to propagate towards the bladder.

80% of urinary tract infections are caused by the Escherichia coli bacterium [ANSES].

The bacterium, found naturally in our intestines, migrates into the bladder and adheres to the uroepithelial cells. This causes the urinary discomfort experienced by so many women. In fact, one in every two women will have a urinary tract infection at least once in her lifetime2. Finally, a third of people who already had a urinary tract infection will develop a new infection within 6 months3.

What are the consequences?

Urinary tract infections are a major public health problem. This is because the most common treatments involve antibiotics. Yet if used repeatedly, there is a risk of developing antibiotic resistance4-5. Moreover, they can sometimes cause side effects, for example they can disturb the vaginal microbiota and consequently affect quality of life and sexuality.

In addition, a recent study has identified a toxin produced by E. coli believed to damage the DNA of bladder cells6. These results raise the issue of improving treatment in patients with recurrent urinary tract infections.

It is best to prevent urinary tract infections by other means whenever possible. Particularly since those at risk increasingly prefer natural remedies.

 

Role of cranberries in urinary tract health

For decades, cranberries have been considered a traditional remedy for urinary tract infections. Several scientific studies have even demonstrated their health potential. In particular, they have proved that drinking cranberry juice reduces the number of urinary tract infections7-8-9-10.

 

If cranberries are so effective, it is partly because they contain type A proanthocyanidin antioxidants (PACs). PACs reduce the adhesion of pathogenic bacteria to uroepithelial cells.

Cranberries also have an antibacterial activity11-12, thus reducing the number of bacterial colonies in addition to their mobility13. Finally, they help to modify the biofilm14-15. A biofilm is a cluster of bacteria attached to a surface. This structure protects the bacteria, allowing them to survive in extreme environmental conditions.

 

ADDEOLIC® provides 200 mg of cranberry, equivalent to 36 mg of PACs/day (validated using the benchmark BL-DMAC method). This dose of PACs was retained by ANSES to demonstrate the ability to prevent bacteria from adhering to urinary mucosa.

 

 

Role of cinnamon and basil essential oils in urinary tract health

Cinnamon oil

Cinnamon owes its antibacterial activity to the presence of cinnamaldehyde16-17. This key molecule is particularly effective against S. aureus and E. coli. Both bacteria are commonly involved in the onset of urinary tract infections17. Cinnamon also prevents E. coli from adhering to epithelial cells18.

One study looked at the action of cinnamaldehyde when added to an E. coli cell culture. The results showed that it alters the assembly of bacterial cellular processes by inhibiting synthesis of DNA, RNA and structural proteins in E. coli18. In other words, cinnamaldehyde inhibited bacterial growth.

Another study has also shown that cinnamon essential oil can eliminate S. aureus cells in stationary phase after 3 days of exposure19.

 

The cinnamon essential oil chemotype in ADDEOLIC® contains trans-cinnamaldehyde (70%-90% Eur. Ph. 6.2).

 

Basil oil

Basil also has many interesting health properties. It notably reduces bacterial growth of S. aureus20.

Like cinnamon, basil is composed mostly of an active molecule: linalool20. This presence of linalool22 gives it bacteriostatic*21 and antispasmodic properties.

*A substance that stops bacterial growth.

 

Researchers have also studied the activity of basil essential oil on bacterial strains of S. aureus. The results demonstrate that the S. aureus strains are sensitive to basil essential oil. In other words, they observed a reduction in the growth of S. aureus bacteria when in contact with basil essential oil.

 

 The basil essential oil chemotype in ADDEOLIC® contains linalool (min. 45%) and 1,8-cineole (min. 2%).

 

Study on the cinnamon and basil essential oils contained in ADDEOLIC®

While 80% of urinary tract infections are caused by Escherichia coli, other bacteria are also frequently found, in particular Klebsiella pneumoniae and Proteus mirabilis.

The following study23 evaluated the antimicrobial activity of the cinnamon and basil essential oils contained in ADDEOLIC® on E. coli, K. pneumoniae and P. mirabilis versus a reference antibiotic for urinary tract infections: sulfamethizole.

The results show that cinnamon and basil essential oils have a better bacteriostatic effect than sulfamethizole (*MIC >512 mg/l) on two strains in particular (E. coli and P. mirabilis). In addition, the dose of cinnamon essential oil was half that currently found in ADDEOLIC® (48 mg/day). Addeolic-antimicrobial-activity.

 

*MIC = Minimum Inhibitory Concentration, i.e. the lowest concentration required to inhibit bacterial growth.

 

 Cinnamon and basil essential oils are powerful allies for naturally fighting intimate discomfort !

 

 

Double-blind study on the effectiveness of ADDEOLIC®

A use study24 was conducted involving 60 women with symptoms of urinary discomfort. The objective was to evaluate the effectiveness of ADDEOLIC®. To this end, a first group of women (30) took 2 ADDEOLIC® capsules per day* for 5 days.

*200 mg of cranberry 20% PACs + 24 mg Chinese cinnamon EO + 14 mg basil EO

Note: The dose of cinnamon essential oil was half that currently found in ADDEOLIC® (48 mg/day)

The second group (30) received a placebo over the same period. Each woman then had to measure and evaluate the improvement in her symptoms by means of a specific questionnaire.

 

Results

After just 3 days, 43% of subjects in the ADDEOLIC® group noted an improvement in symptoms vs. 20% in the placebo group (p=0.05).

addeolic femme97% of subjects in the ADDEOLIC® group also noted a significant improvement in quality of life after 5 days of use (p<0.05).

Finally, 70% of subjects rated ADDEOLIC® as “effective” and 93% as “well tolerated”.

ADDEOLIC® therefore led to a general improvement in the subjects’ symptoms and quality of life at a daily consumption of 480 mg.

 

ADDEOLIC® in short:

  • 3 ingredients scientifically proven to improve urinary comfort
    • A use study conducted in 60 women with symptoms of urinary discomfort
  • A specific essential oil micro-encapsulation technology
  • 480 mg/day of ADDEOLIC® provides a guaranteed 36 mg of PACs (according to the official BL-DMAC method)
  • Reduced adhesion of pathogenic bacteria to uroepithelial cells, due to the cranberry PACs
  • Cinnamon essential oil chemotype: trans-cinnamaldehyde (70%-90% Eur. Ph. 6.2)
  • Basil essential oil chemotype: linalool (min. 45%) and 1,8-cineole (min. 2%)
  • A natural alternative to antibiotics
  • Suitable for vegans
  • Suitable for a “capsule” delivery form
  • Complete regulatory file (Appendices II & III)
  • Free from nanomaterials (Regulation 1169/2011)
  • Contains no allergenic substances (Regulation 1169/2011)

 

 

 

Also in the range, Cranbe’Clear®, a cranberry extract titrated to 20% PACs.

cranbe'clear

 

References

  1. Enquête Harris Interactive pour Synadiet réalisée sur 1506 femmes représentatives de la population française (juin 2021)

  2. GrieblingTL. Urinary tract infection in women. In: LitwinMS, SaigalCS, eds. Urologic Diseases in America. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. Washington, D.C.: GPO; 2007. NIH publication 07–5512:587–619

  3. Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Dis Mon. 2003 Feb;49(2):53-70

  4. Carlet J, Collignon P, Goldmann D et al. Society’s failure to protect a precious resource: Antibiotics. Lancet 2011;378:369–371.

  5. Van Buul LW, van der Steen JT, Veenhuizen RB et al. Antibiotic use and resistance in long term care facilities. J Am Med Dir Assoc 2012;13:568. e1–568.e13.

  6. Chagneau CV, Massip C, Bossuet-Greif N, et al. Uropathogenic E. coli induces DNA damage in the bladder. PLoS Pathog. 2021;17(2):e1009310. Published 2021 Feb 25. doi:10.1371/journal.ppat.1009310

  7. Jepson RG, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2008;CD001321.

  8. Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2012;10:CD001321.

  9. Monique et al Effectiveness of Cranberry Capsules to Prevent Urinary Tract Infections in Vulnerable Older Persons JAGS 62:103–110, 2014

  10. Afshar K, Stothers L, Scott H et al. Cranberry juice for the prevention of pediatric urinary tract infection: A randomized controlled trial. J Urol 2012;188(Suppl 4):1584–1587.

  11. Lee YL, Owens J, Thrupp L et al. Does cranberry juice have antibacterial activity? JAMA 2000;283:1691.

  12. Laplante KL, Sarkisian SA, Woodmansee S et al. Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus species. Phytother Res 2012;26:1371–1374.

  13. Hidalgo G, Chan M, Tufenkji N.Inhibition of Escherichia coli CFT073 fliC expression and motility by cranberry materials. Appl Environ Microbiol. 2011;77(19):6852-6857

  14. Vollmerhausen TL, Conneely A, Bennett C, Wagner VE, Victor JC, O’Byrne CP. Visible and UVA light as a potential means of preventing Escherichia coli biofilm formation in urine and on materials used in urethral catheters. J Photochem Photobiol B. 2017 May;170:295-303.

  15. Sun J, Marais JP, Khoo C, et al. Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coliJ Funct Foods. 2015;17:235-242.

  16. Antibacterial activity and mechanism of cinnamon essential oil against Escherichia Coli and Staphylococcus aureus, 2016.

  17. Antibacterial Effect of some Herbal plants against Pathogenic Bacteria Isolated from Patients with Urinary Tract Infections (UTI), 2019

  18. New insights into the antimicrobial action of cinnamaldehyde towards echerichia coli and its effects on intestinal colonization of mice, 2021.

  19. Identification of essential oils with activity against stationary phase Staphylococcus aureus, 2020.

  20. Antibacterial Activity of Ocimum basilicum Essential Oil and Linalool on Bacterial Isolates of Clinical Importance, 2015

  21. Antibacterial activity of Ocimum basilicum L. essential oil against Gram-negative bacteria, 2016.

  22. Rachid Soulimani, Rakesh Kumar Joshi. Toxicological aspects and pharmaco-therapeutic properties of linalool, a natural terpene derivative of essential oils: Literature studies. Am J Essent Oil Nat Prod 2020

  23. ADIPharm Tests performed according to National Committee for Clinical Laboratory Standards (NCCLS) and following the international standards ISO 20776-1

  24. Evaluation de l’efficacité du complément alimentaire Addeolic® sur l’inconfort urinaire. Biofortis, 2012.