Cranbe’Clear: preserving your intimate well-being

Cranbe’Clear® is a cranberry extract. Its 20% proanthocyanidins promote urinary tract health and comfort.

Why choose Cranbe’Clear©?

20% PACs (BL-DMAC)

180 mg/d to reach a dose of 36 mg/d of PACs

Annexes II and III of the French “Arrêté Plante” decree

What is Cranbe’Clear©?

Cranbe’Clear® is a cranberry extract also known as cranberry(Vaccinium macrocarpon Aiton). Native to North America, particularly the northern United States and Canada, it naturally contains 20% proanthocyanidins (PACs), measured by the improved and specific BL-DMAC method. Cranbe’Clear® helps reduce the adhesion of E. Coli bacteria to urinary tract cells.

Find out more about cranberries

Cranbe’Clear : dose of effectiveness.

On the basis of clinical studies, ANSES found that the dose of 36 mg PACs/day from cranberry showed an anti-adhesion effect of certain bacteria (mainly E. coli) to the urinary mucosa. Consequently, it has also validated BL-DMAC as the reference method for confirming this dose: 100 mg of Cranbe’Clear® contains a minimum of 20 mg PACs per dosage, i.e. 180 mg to obtain the recommended dose of 36 mg PACs.

BL-DMAC : our benchmark analysis method.

Several methods exist for measuring PACs, but results vary from one method to another. We used BL-DMAC, recognized as a reliable, rapid and highly accurate method. What’s more, it has been validated ¹ by five international laboratories and published in the Journal of the science of food and agriculture. It is thus confirmed as the reference method for measuring PAC content. The use of such a method is a guarantee of confidence. It guarantees well-dosed products, and therefore efficiency for the end consumer.

^{1. Prior R. et al.Journal of the Science of Food and Agriculture, vol 90, Issue 9. 21 april 2010.http://www.dmac-asso.org/}

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Cranberry

The cranberry is also known as cranberry(Vaccinium macrocarpon Aiton). Native to North America, this wonderful little red berry is a feminine ally par excellence. In fact, it’s becoming increasingly popular in Europe, especially with women.

Our intestinal microbiota is made up of billions of bacteria, viruses and fungi essential to the body’s proper functioning. The E. coli bacterium is naturally present there, where it is harmless. When it migrates to the bladder or urinary tract, however, it can cause urinary discomfort.

Cranberries are unique in that they contain type A proanthocyanidins. These PACS inhibit the adhesion of certain bacteria to urinary epithelial cells, thereby reducing the prevalence of urinary discomfort ^1-2.

^{1. Ermel G, Georgeault S, Inisan C, Besnard M. J Med Food. 2012;15(2):126-34.

2. Liu Y, Black MA, Caron L and Camesano TA.Biotechnol Bioeng 93:297 (2006).}

Culture and production

The cranberry is a woody, creeping plant in the Ericaceae family. The first harvests can begin 3 years after planting. Buds form in autumn and require protection over winter to flower in spring. Pollination then leads to the formation of white berries, which turn bright red before being harvested in September or October.

Harvesting takes place by flooding the fields, so as to naturally draw the berries towards their ends and avoid any risk of fruit “breakage” due to contact with equipment or tools. The berries are then collected.

Cranberries can be used fresh, dried or dehydrated, as well as to make juice or extracts. Cranberry pomace, a by-product of juice pressing, is also used for extraction, thanks to its anthocyanin content.

Studies on the effects of cranberry on the incidence of urinary discomfort

Howell AB et al. 2010 study

A multicenter ^study1 evaluated the effect of cranberry supplementation containing different doses of PACs (18, 36 and 72 mg PACs/day) on E. coli anti-adhesion activity in 32 healthy women (Japan, Hungary, Spain and France) with no urinary tract infection at the time of selection.

Initial results showed significant anti-adhesion activity in urine collected from volunteers who consumed cranberry compared with placebo (p<0.001). Furthermore, the results of the adhesion index measurement on epithelial cells (see figure below) revealed that after cranberry supplementation with 36 or 72 mg PACs, the bacterial adhesion index was significantly lower than when the supplement was titrated to 18 mg PACs.

Thus, 36 mg PACs/day offers optimal anti-adhesive activity to limit bacterial adhesion to urethral wall cells.

^{1. Howell AB, Botto H, Combescure C et al.BMC Infect Dis 2010;10:94.}

Study by Caljouw et al. 2014

Dutch researchers conducted a multicenter ^study1 of 516 women to observe the effect of daily intake of cranberry titrated to 18 mg PACs/day for one year on the incidence of urinary discomfort. At inclusion, subjects were in good health but had a high baseline risk of urinary discomfort.

The results revealed that a daily intake of cranberry dosed at just 18 mg PACs/day reduced the incidence of urinary discomfort by 26%.

^{1. Caljouw et al. JAGS 62:103-110, 2014}